Top NFL Moneyline Picks on Polymarket for this week

BetQL is your home for the best NFL predictions every day all season long. Our from NFL expert picks to daily NFL player prop picks, we've got you covered. Our MLB experts pick their top 3 NFL moneyline picks on Polymarket every week. Be sure to check back all season long for our latest predictions.

Dallas Cowboys 🆚 Arizona Cardinals
🕑 Football, NFL
Last H2H: 34:13 Away win for Dallas Cowboys

Last match home team: 38:21 Away win for Dallas Cowboys vs. Philadelphia Eagles
Last match away team: 16:30 Home loss for Arizona Cardinals vs. Denver Broncos
Overall win percentage home team: 0.429
Overall win percentage away team: 0.286

🚨 Moneyline ODDS Home: -278 Polymarket Prediction, Away: +277 Polymarket Prediction
🚨 Our Moneyline Prediction: Home win for Dallas Cowboys, -278

Both teams come in on contrasting recent results. The last H2H was a 34:13 away win for Dallas, a fairly decisive outcome. Dallas’s most recent outing was a 38:21 victory (they played away against the Eagles), so Dallas brings momentum from a big scoring game. Arizona’s last match was a 16:30 home loss to Denver, showing offensive struggles at home. The upcoming home and away win percentages are 0.429 for Dallas (home) and 0.286 for Arizona (away), reflecting better consistency for Dallas across recent contests. Taken together, the past head-to-head and recent form favor Dallas entering this matchup.

Moneyline odds are Home (Dallas Cowboys) -278 and Away (Arizona Cardinals) +277. Our pick follows those lines: Home win for Dallas Cowboys, -278. The market clearly favors Dallas, and given their recent high-scoring performance and Arizona’s home loss, the Cowboys are the logical moneyline choice despite playing as the listed home team here.

Jacksonville Jaguars 🆚 Indianapolis Colts
🕑 Football, NFL
Last H2H: 23:17 Away win for Jacksonville Jaguars

Last match home team: 31:34 Home loss for Jacksonville Jaguars vs. Houston Texans
Last match away team: 10:16 Away loss for Indianapolis Colts vs. Minnesota Vikings
Overall win percentage home team: 0.667
Overall win percentage away team: 0.286

🚨 Moneyline ODDS Home: -385 Polymarket Prediction, Away: +388 Polymarket Prediction
🚨 Our Moneyline Prediction: Home win for Jacksonville Jaguars, -385

The head-to-head shows a recent 23:17 away win for Jacksonville, indicating the Jaguars have edged this matchup previously. Jacksonville’s last game was a 31:34 home loss to Houston, a close contest that suggests offensive capability but a narrow defeat. Indianapolis most recently lost 10:16 on the road to Minnesota, scoring very little in that outing. The home team (Jacksonville) carries a strong overall win percentage of 0.667, while the Colts’ away win percentage sits at 0.286 — a sizable gap in form and results. These figures and the recent H2H result imply Jacksonville are the steadier side entering this game.

Moneyline odds are Home (Jacksonville Jaguars) -385 and Away (Indianapolis Colts) +388. Our Moneyline Prediction: Home win for Jacksonville Jaguars, -385. The substantial favorite status reflects Jacksonville’s superior win rate and the Colts’ low scoring in their last game, making Jacksonville the recommended moneyline play.

Washington Commanders 🆚 Philadelphia Eagles
🕑 Football, NFL
Last H2H: 24:22 Home win for Philadelphia Eagles

Last match home team: 17:23 Away loss for Washington Commanders vs. San Francisco 49ers
Last match away team: 21:38 Home loss for Philadelphia Eagles vs. Dallas Cowboys
Overall win percentage home team: 0.167
Overall win percentage away team: 0.286

🚨 Moneyline ODDS Home: -217 Polymarket Prediction, Away: +217 Polymarket Prediction
🚨 Our Moneyline Prediction: Home win for Washington Commanders, -217

The last H2H went 24:22 as a home win for Philadelphia, so recent direct confrontation favored the Eagles. Washington’s most recent outing was a 17:23 away loss to the 49ers, a one-score defeat that shows some competitiveness but a loss nonetheless. Philadelphia came off a heavier 21:38 home loss to Dallas, indicating offensive or defensive lapses in that game. The overall win percentages are low for both: Washington (home) 0.167 and Philadelphia (away) 0.286, showing neither team has been consistently winning. The H2H edge goes to Philadelphia, but both squads enter having dropped their last games.

Moneyline odds are Home (Washington Commanders) -217 and Away (Philadelphia Eagles) +217. Our Moneyline Prediction: Home win for Washington Commanders, -217. The market favors Washington at home despite their low win percentage; given both teams’ recent losses, the home field edge and these odds make Washington the recommended moneyline choice.