College Football Week 4 Preview

College football is back and we're ready to share all our thoughts on the biggest games of Week 4. We've got all the best NCAAF Predictions for every conference all season long. From futures picks to AP top 25 picks and our weekly College Football Expert picks we've got you covered. Let's take a look at what NCAAF week 4 has in store for us.

Northwestern at Indiana (5)

We have trending NCAAF Week 4 betting tips for the exciting NCAAF game between Indiana and Northwestern on Friday, September 25, 2026, at Memorial Stadium. Both teams are looking to make a statement in this matchup, and anticipation is building for what promises to be a spectacular contest.

Indiana Hoosiers Analysis

Indiana comes into this game with an impressive current ranking of 4 in the league standings, boasting a perfect record of 3 wins and 0 losses. Their offense has been rolling, scoring a total of 145 points while only allowing 16 points against them. They are coming off a dominant performance against Western Kentucky, winning 38-0, which adds to their momentum.

Last 5 Games:

• 38 - 0 win vs. Western Kentucky (September 19, 2026)
• 55 - 0 win vs. Howard (September 12, 2026)
• 52 - 16 win vs. North Texas (September 5, 2026)
• 27 - 21 win vs. Miami FL (January 19, 2026)
• 56 - 22 win vs. Oregon (January 9, 2026)

The Hoosiers have been led by an outstanding player whose contributions on both sides of the ball have been crucial. Unfortunately, detailed personal statistics were not available, but their recent performances demonstrate the team's strength and focus.

Northwestern Wildcats Analysis

On the other hand, Northwestern is ranked 35 in the league standings and holds a standing record of 2 wins and 0 losses. They have scored a total of 75 points while allowing 25 points against them. Their most recent game was a solid 41-7 victory over Colorado, solidifying their confidence heading into this tough matchup.

Last 5 Games:

• 41 - 7 win vs. Colorado (September 19, 2026)
• 34 - 18 win vs. South Dakota State (September 5, 2026)
• 34 - 7 win vs. Central Michigan (December 26, 2025)
• 13 - 20 loss vs. Illinois (November 29, 2025)
• 38 - 35 win vs. Minnesota (November 22, 2025)

Northwestern's top player has also been a key asset for the team, although specific personal statistics could not be retrieved.

Head-to-Head Statistics

Regarding their head-to-head meetings, Indiana and Northwestern have shown to compete fiercely against each other. In their most recent encounters, Indiana won convincingly, highlighting their upper hand in this rivalry.

Recent H2H Results:

• Indiana 38 - 7 Northwestern (2026)
• Indiana 27 - 20 Northwestern (2025)

Predictions for the Game

1. Moneyline Prediction: Our NCAAF prediction is that Indiana will secure victory with a moneyline of -2000 at Fanatics Sportsbook, making them a strong favorite in this game.
2. Spread Prediction: Best CFB point spread is in favor of Indiana, projected to win by -19.5 points, listed at -125 odds on Fanatics Sportsbook. This indicates confidence in Indiana's ability to dominate the scoreline.
3. Points Total Betting Market: For the totals, the betting market favors over 48.5 points, with odds of -120 at Fanatics Sportsbook. Both teams have shown the potential to score, adding excitement to this aspect of the game.

In summary, this game between Indiana and Northwestern not only features two competitive teams in their current forms but also allows fans to expect high-stakes roles for both defenses and offenses. With Indiana's comprehensive dominance showcased in recent games and strong betting odds in their favor, it will be fascinating to see if they can maintain their winning streak. Keep an eye on this spectacular showdown!

Check out our full game analysis here.

UCLA at Maryland

We have CFB Week 4 betting tips for the exciting upcoming game between Maryland and UCLA, set to kick off on Saturday, 26th September 2026, at Maryland Stadium. While the referee for this game is yet to be announced, both teams are looking to make a strong statement this season.

Maryland Terps Overview

Maryland enters the game with a current standing of 2 wins and 1 loss this season, showcasing their potential after three games. The Terps have scored an impressive 126 points while allowing just 49, resulting in a positive point difference of 77. Maryland's last five games have seen them on a mixed trajectory, with results showcasing both strengths and weaknesses:

• Maryland vs. Virginia Tech: 26 - 35 (Loss)
• Connecticut vs. Maryland: 14 - 38 (Win)
• Maryland vs. Hampton: 62 - 0 (Win)
• Michigan State vs. Maryland: 38 - 28 (Loss)
• Maryland vs. Michigan: 20 - 45 (Loss)

With standout performances, Maryland continues to build on last season's foundation, though the specific statistics for individual players from the team are not fully available.

UCLA Bruins Rundown

On the other side, UCLA comes into this matchup with an unbeaten record of 3 wins in 3 games, scoring a total of 125 points but conceding 72, which grants them a healthy point differential of 53. Their execution on the field has solidified their place among the top contenders. Here’s a look at UCLA's last five outings:

• UCLA vs. Purdue: 52 - 38 (Win)
• UCLA vs. San Diego State: 28 - 10 (Win)
• California vs. UCLA: 24 - 45 (Win)
• USC vs. UCLA: 29 - 10 (Loss)
• UCLA vs. Washington: 14 - 48 (Loss)

Despite the availability of individual player statistics being limited, the Bruins’ collective efforts reflect a well-synchronized team, demonstrating their capacity to maintain momentum as they approach this game.

Head-to-Head Statistics

In terms of previous encounters, Maryland and UCLA have faced off in the past, adding a layer of intrigue to this matchup. The most recent scorelines show:

• Maryland: 40
• UCLA: 27

Their historical games have often been closely contested, setting the stage for another thrilling confrontation.

Game Predictions

1. Our NCAAF prediction is: The moneyline leans towards an away win for UCLA at -120 via DraftKings Sportsbook, suggesting confidence in their unbeaten run.
2. Best CFB point spread is: Home win for Maryland with a spread of +2.5 points at -116 from DraftKings Sportsbook, giving them an edge in close scoring situations.
3. Points total betting market: The market anticipates under 58.5 points at -119 on DraftKings Sportsbook, hinting at a potentially defensive struggle.

Summary

As Maryland hosts UCLA, fans can expect a game filled with high stakes and competitive spirit. While UCLA has been a powerhouse this season, the Terps will strive to leverage their home-court advantage. The combination of team dynamics, historical context, and predictions creates an enticing environment for viewers. Whether you lean towards Maryland's home advantage or UCLA's strong start, one thing is certain: this game is sure to be a compelling contest full of excitement.

Check out our full game analysis here.

Notre Dame (3) at Purdue

We have college football week 4 betting tips for the exciting NCAAF game between Purdue and Notre Dame on Saturday, September 26, 2026. This highly anticipated game will take place at the renowned Ross-Ade Stadium, where fans will be eager to see the action unfold.

Home Team: Purdue

Purdue enters this game having a rough start to the season, currently showing a league standing of 1 win and 2 losses in their previous games. Their offensive strategy seems to be struggling a little, but they are at home, which often provides a significant advantage. Here are their last five games:

• Lost to UCLA: 38 - 52
• Lost against Wake Forest: 36 - 38
• Won against Indiana State: 44 - 19
• Lost to Indiana: 3 - 56
• Lost to Washington: 13 - 49

Purdue's key player has not been highlighted due to insufficient statistics; however, their performance in the earlier games will be crucial in taking on a formidable opponent like Notre Dame.

Away Team: Notre Dame

Notre Dame comes into this game with a solid record, having won all three of their preceding games. They are ranked 15th in the league standings, showcasing an impressive scoring ability and strong defense. The Fighting Irish have outscored their opponents significantly, indicating a high level of performance. Their recent results look like this:

• Won against Michigan State: 27 - 10
• Won against Rice: 52 - 0
• Won against Wisconsin: 41 - 13
• Won against Stanford: 49 - 20
• Won against Syracuse: 70 - 7

Like Purdue, Notre Dame's standout player hasn't been specified, but their balanced offense and tight-knit defense have proven critical in their games.

Head-to-Head Statistics

In their recent encounters, Notre Dame has historically held the advantage over Purdue. Their previous meetings have often ended in significant victories for the Fighting Irish, as seen in their last results. The last three games resulted in Notre Dame scoring 49 points against Purdue's 3, illustrating the considerable gap in performance.

Predictions for the Game

1. Moneyline Prediction: Our NCAAF prediction is that the away win for Notre Dame holds strong at -10000 via FanDuel Sportsbook.
2. Spread Prediction: The best CFB point spread is home win for Purdue with +27.5 points at -104 from FanDuel Sportsbook; this could provide some breathing room for Purdue against a tough opponent.
3. Points Total Betting Market: The totals market indicates an over at 57.5 points at -122 from FanDuel Sportsbook, hinting at a high-scoring affair given both teams' offensive capabilities.

Summary

As Purdue battles Notre Dame, fans can expect an electrifying game characterized by contrasting early season fortunes. With Purdue looking to leverage their home advantage against a dominant Notre Dame team, this game promises thrilling moments and strategic plays. Our predictions align toward Notre Dame’s overall superiority this season, while Purdue's potential to cover the spread could keep the excitement alive. Keep an eye out for what promises to be a memorable college football clash!

Check out our full game analysis here.